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. 2018 Sep 20;3(18):e121549. doi: 10.1172/jci.insight.121549

Figure 3. Transition toward restorative macrophages during regeneration is stunted in chronically infected muscle.

Figure 3

(A) Absolute number of total macrophages (CD45+CD11b+Ly6g–CD68+) per gram of skeletal muscle by flow cytometric analysis (n = 10–12 mice/group). (B) Representative flow plots and graphical summary of macrophage subsets (CD206hi/loLy6chi/lo) in naive and infected skeletal muscle at 0, 1, 4, and 10 days after CTX-induced injury (n = 10–12 mice/group). (C) Change in frequency of CD206hiLy6chi transitional macrophages 1 day after CTX-induced injury (n = 10–12 mice/group). Results are cumulative of 3 experiments of n = 3–4/group/experiment; error bars represent SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by ANOVA with Tukey’s multiple-comparisons test (A) or ANCOVA (C).