Figure 3. Human haptoglobin, central venous pressure, hematocrit, and pulmonary artery occlusion pressure measurements at serial time points.

The format is similar to Figure 1, except that human haptoglobin, central venous pressure, hematocrit, and pulmonary artery occlusion pressure are measured over 96 hours after S. aureus challenge in canines receiving haptoglobin or no haptoglobin with (A, C, E, G) or without RBC exchange transfusion (B, D, F, H) Comparisons of all variables (except survival) were made based on contrasts in linear mixed models, which allow us to account for repeated measurements of each animal and the actual pairing of animals within each cycle.