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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Diabetes. 2017 Jan 5;66(4):1062–1073. doi: 10.2337/db16-0755

Fig 1.

Fig 1

Serotonin depletion interferes with the weight-loss maintenance after central GLP-1R activation (A). While daily central EX4 injections in control rats led to a potent reduction of body weight, the weight loss impact of EX4 was markedly attenuated in rats depleted of serotonin by PCPA suggesting that intact serotonin synthesis is needed for a full expression of EX4-induced weight loss. PCPA/VEH animals did not increase in weight. n = 3–6 per each treatment group. Activation of central GLP-1R ameliorated changes in serotonin receptor genes in the hypothalamus induced by food restriction (B) and also increased serotonin turnover in the hypothalamus (C). *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001 compared to vehicle-treated rats. #p < 0.05, ##p < 0.01, ###p < 0.005 compared to pair-fed rats.