Fig. 2.

Stress and eicosanoids directly influence inflammation. However, the relationship between stress and eicosanoids is not well established. Eicosanoids activate certain components of CNS-mediated stress response pathway, while stress mediators are known to influence synthesis of certain eicosanoids. It is possible that stress mediators and eicosanoid-synthesizing enzymes influence each other, should their basal levels be disrupted. However, additional research is needed to elucidate the exact pathways and mediators involved in this interaction