Table 1. Epidemiological model including exposures, potential confounders and outcome variables.

Exposure	Potential confounders	Outcome
Maternal state stress DASS-42a -Depression -Anxiety -Stress PRAb Major life events	Model 2 Personal traits Age BMI Parity Maternal trait stress: NEO-FFI -neuroticism,conscientiousness	Primary outcome: AFCEc Secondary outcomes: Plasma concentrations of maternal and fetal cortisol and cortisone
	Model 3 Lifestyle Smoking Alcohol
	Model 4 Health Chronic disease Gestational complications Asthma medication
	Model 5 Delivery Gestational age Gender Delivery mode Placental weight Placental symmetry Delivery to maternal blood

^aDASS-42 is the results from the depression anxiety stress scales.

^bPRA is the results from the questionnaire on pregnancy related anxiety.

^cAFCE is the adjusted fetal cortisol response.