. 2018 Nov 15;13(11):e0207323. doi: 10.1371/journal.pone.0207323

Table 2. Longitudinal assessment of trabecular microarchitecture of the right proximal tibial metaphysis in three doses groups of rats.

Trabecular structural properties	Dose (Gy)	Age (week)
Trabecular structural properties	Dose (Gy)	4	5	6	7	8	9	10	11	12	14
*BMD (g.cm^-3)*
	0.83	0.156 ± 0.035	0.163 ± 0.027	0.150 ± 0.024	0.171 ± 0.029	0.183 ± 0.04	0.172 ± 0.051	0.179 ± 0.044	0.185 ± 0.026	0.200 ± 0.031	0.205 ± 0.037 ^α
	1.65	0.162 ± 0.028	0.173 ± 0.046	0.163 ± 0.038	0.179 ± 0.041	0.121 ± 0.031	0.131 ± 0.016	0.131 ± 0.02	0.111 ± 0.036	0.125 ± 0.035	0.139 ± 0.045
	2.47	0.173 ± 0.015	0.192 ± 0.045	0.184 ± 0.029	0.186 ± 0.035	0.141 ± 0.051	0.14 ± 0.018	0.121 ± 0.051	0.121 ± 0.036	0.132 ± 0.034	0.128 ± 0.042 ^γ
*BV/TV (%)*
	0.83	18.78 ± 5.23	20.05 ± 4.12	21.89 ± 6.42	22.27 ± 7.13	20.72 ± 4.13	21.07 ± 3.12	19.94 ± 6.14	21.51 ± 7.12	22.78 ± 5.12	27.56 ± 7.21 ^α
	1.65	20.55 ± 8.23	21.52 ± 7.4	22.72 ± 8.24	23.77 ± 5.13	19.74 ± 8.23	19.77 ± 5.13	19.34 ± 8.13	22.3 ± 6.12	21.46 ± 7.24	23.76 ± 11.23
	2.47	22.47 ± 10.12	23.63 ± 8.23	20.12 ± 7.40	21.23 ± 6.40	18.75 ± 8.24	19.34 ± 7.23	18.84 ± 5.34	19.44 ± 6.14	17.76 ± 8.42	19.14 ± 9.23
*Tb.Th (mm)*
	0.83	0.078 ± 0.012	0.083 ± 0.012	0.081 ± 0.012	0.086 ± 0.013	0.087 ± 0.012	0.079 ± 0.011	0.084 ± 0.012	0.085 ± 0.015	0.087 ± 0.015	0.107 ± 0.015 ^α
	1.65	0.093 ± 0.014	0.094 ± 0.011	0.086 ± 0.010	0.078 ± 0.010	0.075 ± 0.010	0.074 ± 0.012	0.076 ± 0.010	0.072 ± 0.012	0.062 ± 0.013	0.055 ± 0.006 ^β
	2.47	0.103 ± 0.011	0.105 ± 0.011	0.097 ± 0.012	0.089 ± 0.015	0.093 ± 0.011	0.094 ± 0.011	0.088 ± 0.012	0.078 ± 0.011	0.076 ± 0.011	0.067 ± 0.007 ^γ
*Tb.N (mm^-1)*
	0.83	2.208 ± 0.457	2.104 ± 0.435	2.453 ± 0.508	2.578 ± 0.533	2.473 ± 0.482	2.447 ± 0.477	2.642 ± 0.515	2.577 ± 0.483	2.82 ± 0.529	2.946 ± 0.552 ^α
	1.65	1.972 ± 0.379	1.863 ± 0.358	2.15 ± 0.414	2.12 ± 0.408	2.234 ± 0.414	2.163 ± 0.401	2.22 ± 0.411	2.41 ± 0.402	2.33 ± 0.388	2.601 ± 0.434 ^β
	2.47	2.651 ± 0.496	2.55 ± 0.477	2.678 ± 0.501	2.489 ± 0.466	2.102 ± 0.359	1.961 ± 0.335	2.16 ± 0.369	2.1 ± 0.326	1.83 ± 0.284	2.072 ± 0.321 ^γ
*Tb.Sp (mm)*
	0.83	0.839 ± 0.187	0.817 ± 0.182	0.784 ± 0.174	0.763 ± 0.159	0.819 ± 0.17	0.71 ± 0.151	0.766 ± 0.163	0.751 ± 0.153	0.85 ± 0.173	0.794 ± 0.162
	1.65	0.646 ± 0.133	0.612 ± 0.126	0.671 ± 0.138	0.726 ± 0.14	0.752 ± 0.146	0.781 ± 0.154	0.751 ± 0.148	0.795 ± 0.145	0.831 ± 0.152	0.855 ± 0.156 ^β
	2.47	0.752 ± 0.131	0.723 ± 0.126	0.723 ± 0.126	0.711 ± 0.124	0.777 ± 0.135	0.795 ± 0.134	0.743 ± 0.125	0.773 ± 0.126	0.892 ± 0.145	0.929 ± 0.151 ^γ
*Conn.Dn (mm^-3)*
	0.83	189.8 ± 32.5	195.5 ± 39.1	234.7 ± 46.9	188.4 ± 32.6	178.5 ± 30.9	189.3 ± 32.8	234.1 ± 34.5	173.2 ± 25.5	164.3 ± 24.2	157.9 ± 29.2 ^α
	1.65	263.4 ± 40.9	258.2 ± 40.1	273.8 ± 42.5	295 ± 54.2	219.5 ± 40.3	232.6 ± 42.7	266.4 ± 45.2	145.3 ± 24.6	132.1 ± 22.4	144.7 ± 26.1 ^β
	2.47	208.8 ± 30.3	220.2 ± 31.9	255.2 ± 37	210.2 ± 30.5	233.2 ± 43.2	189.2 ± 35.1	225.8 ± 41.8	205.2 ± 27.7	178.3 ± 24.1	186.6 ± 27.4

Values are expressed as Mean ± SD, n = 11/group. Within each dose (0.83, 1.65 and 2.47 Gy), different symbols (α, β, γ) denote statistical significance (p < 0.05) from 4^th to 14^th week of age. Abbreviations: BMD, bone mineral density; BV/TV, bone volume fraction; Tb.Th, trabecular thickness; Tb.N, trabecular number; Tb.Sp, trabecular spacing; Conn.Dn, connectivity density.