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. 2018 Nov 15;13(11):e0207293. doi: 10.1371/journal.pone.0207293

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© 2018 Mücke et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — Course of (A) sphingosine, (B) sphinganine, (C) sphinganine-1-phosphate, (D) C16-dihydroceramide (C16DHC), (E) C18- and (F) C20-ceramide (C18/C20Cer) in patients with no virologic events from baseline (BL) over a follow-up (FU) period of four years (1–4). While C18Cer levels decrease, all other sphingolipid parameters are continuously increasing over time. Statistically significant differences are indicated by asterisks. "*"p<0.05, "**"p<0.01, "***"p<0.001. Bars depict mean +/- standard mean error.