Table 4. Correlations of serum sphingolipids of all patients (n = 98) with age, body mass index (BMI), aspartate transferase (AST), alanine transferase (ALT), cholesterol (Chol), triglycerides (TG), transient elastography (TE), alpha-fetoprotein (AFP), viral load (VL) and hepatitis B virus surface antigen (HBsAg).
| SL | Age | BMI | AST | ALT | Chol | TG | TE | AFP | VL | HBsAg |
|---|---|---|---|---|---|---|---|---|---|---|
| Sphingosine | 0.228* | 0.234* | -0.035 | 0.077 | 0.014 | 0.119 | 0.071 | 0.172 | -0.005 | -0.064 |
| Sphinganine | 0.267* | 0.218* | 0.013 | 0.120 | 0.111 | 0.146 | 0.014 | 0.070 | -0.013 | -0.034 |
| Sphingosine-1-phosphate | -0.129 | -0.048 | 0.158 | 0.115 | -0.040 | -0.040 | 0.070 | 0.194 | -0.063 | -0.059 |
| Sphinganine-1-phosphate | -0.108 | -0.027 | 0.155 | 0.053 | -0.097 | -0.025 | -0.008 | 0.188 | 0.034 | -0.113 |
| C24Cer | 0.330*** | 0.120 | 0.110 | 0.103 | 0,667*** | 0.339*** | -0.036 | 0.075 | -0.065 | -0.070 |
| C16Cer | 0.034 | -0.153 | 0.004 | -0.013 | 0.416*** | 0.070 | -0.017 | 0.020 | 0.101 | -0.035 |
| C14Cer | 0.064 | -0.100 | -0.061 | -0.094 | 0.159 | 0.052 | -0.038 | 0.009 | 0.098 | 0.159 |
| C18Cer | 0.160 | -0.011 | 0.105 | 0.064 | 0.423*** | 0.173 | 0.112 | -0.005 | 0.007 | -0.034 |
| C20Cer | 0.094 | 0.027 | 0.103 | 0.168 | 0.290** | 0.292** | 0.044 | 0.031 | -0.131 | -0.043 |
| C24:1Cer | 0.195 | 0.034 | 0.170 | 0.068 | 0.518*** | 0.188 | 0.006 | 0.129 | -0.022 | -0.041 |
| C16DHC | -0.046 | -0.162 | -0.004 | 0.036 | 0.056 | 0.100 | -0.038 | 0.059 | 0.045 | 0.243 |
| C18DHC | 0.196 | 0.216 | 0.191 | 0.037 | 0.413*** | 0.218 | -0-018 | 0.036 | -0.143 | -0.181 |
| C24DHC | 0.239* | 0.197* | 0.087 | 0.146 | 0.603*** | 0.260* | 0.059 | 0.114 | -0.063 | -0.051 |
| C24:1DHC | 0.226* | 0.211* | 0.151 | 0.140 | 0.433*** | 0.240* | 0.106 | 0.113 | -0.066 | -0.211 |
Correlations are evaluated by Spearman’s rank correlation coefficient rho (r). Significant correlations are shown in bold and are indicated in the corresponding figures:
*p<0.05
**p<0.01
***p<0.001. Missing data: cholesterol and triglyceride levels were missing in 2 patients, AFP levels were missing in 3 patients, HBsAg levels are missing in 27 cases.