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. 2018 Oct 24;17(19-20):2335–2348. doi: 10.1080/15384101.2018.1526598

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Figure 9. — The roles of p27 in cell cycle regulation and tumor development. (a) The mechanism of p27 in cell cycle. P27 is ubiquitylated and degraded in late G1, S and G2 phases by SCFSkp2 in the nucleus. P27 phosphorylated at S10 is ubiquitylated by the KPC complex when exported to the cytoplasm. (b) Contributions of the study of cell cycle regulation by P27. The mechanism of p27 in cell cycle. P27 induces cell cycle arrest in the G1 phase by inhibiting the formation of cell cycle-dependent complexes CDK6/CCND1.