Figure 2. The metabolic outcomes of obesity-associated adipose tissue fibrosis are controversial.

Excess collagen deposition may reduce adipocyte hypertrophy and consequently preserve adipocyte function. On the other hand, rigid matrix may exert shear stress on expanding adipocytes, leading to adipocyte cell death and consequent inflammation. These two possibilities are proposed to have countervailing effects on metabolic outcomes. Illustrated by Rachel Davidowitz.