Skip to main content
. 2018 Oct 18;3(20):e121900. doi: 10.1172/jci.insight.121900

Figure 2. GJA1-20k is upregulated after subacute and chronic heart failure.

Figure 2

(A) Western blot of protein lysates isolated from mouse hearts with subacute ischemic cardiomyopathy (ICM) induced by 3-week occlusion of the LAD coronary artery. The blots are probed with an antibody for Cx43 C-terminus and an actin antibody. (B) GJA1-20k expression is normalized to actin, and the data are shown as mean fold change ± SEM (n = 4). *P < 0.05, Mann-Whitney U test. (C) Western blot of protein lysates isolated from either nonfailing human hearts or hearts with end-stage ischemic cardiomyopathy. The blots are probed with a Cx43 C-terminus antibody and an actin antibody. (D) GJA1-20k expression is normalized to actin, and the data are shown as mean fold change ± SEM (n = 6). **P < 0.01, Mann-Whitney U test.