Figure 2. Ketoprofen improves cutaneous pathology and skin thickness in open-label study.

(A) In the open-label trial, a 6-mm cutaneous punch biopsy was performed before and after ketoprofen therapy. The cutaneous histopathology score was calculated according to the predefined parameters, as described. Violin plot of the change (Δ) represents the value of the posttreatment minus the pretreatment score; a negative score indicates improvement. (B) For the open-label study, skin thickness was measured clinically by caliper before and after a 4-month exposure to daily ketoprofen therapy (n = 16). (****P < 0.0001, ***P = 0.0006, paired t test).