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. 2018 Oct 18;3(20):e123467. doi: 10.1172/jci.insight.123467

Figure 10. Pharmacological correction of CFTR restores ASL depth after IAV infection.

Figure 10

NHBEs were grown at an air-liquid interface and infected with A/California/07/2009 at a MOI of 1 for 48 hours. Lumacaftor (10 μM) was given via the basolateral compartment 1 hour p.i. ASL depth was measured by μOCT imaging. (A) Representative images are displayed from μOCT imaging of uninfected NHBEs, infected NHBEs, and infected NHBEs with lumacaftor treatment. (B) ASL was restored to uninfected levels after treatment with lumacaftor. Data are plotted as mean ASL depth ± SEM, with n = 6–10 per group across 2 donors. Data were analyzed by 1-way ANOVA with a post hoc Tukey test for multiple comparisons. *P < 0.0001 compared with noninfected controls, #P < 0.04 compared with IAV.