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. 2018 Oct 4;3(19):e122788. doi: 10.1172/jci.insight.122788

Figure 4. miR-31 is differentially expressed in treatment-naive pediatric Crohn’s disease (CD) samples.

Figure 4

miR-31 expression is significantly upregulated in the colon (A) and ileum (B) of treatment-naive pediatric CD samples (colon, n = 76; ileum, n = 60) compared with pediatric NIBD samples (colon, n = 48; ileum, n = 50). Principal components analysis of miRNA expression profiles from small RNA-seq results in distinct clusters of NIBD and CD patients for colon (C) and ileum (D) samples. Points are colored according to miR-31 expression (blue–gold, low–high). Significance determined by a 2-tailed unpaired Student’s t test where P < 0.05. Data presented as mean ± SEM.