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. 2018 Oct 18;3(20):e97957. doi: 10.1172/jci.insight.97957

Figure 7. Serum levels of D-serine reflect kidney function in patients with AKI.

Figure 7

(A) D-serine, D-asparagine, D-alanine, D-proline, and D-leucine are detected in the plasma of AKI patients. Among these, the D-serine/L-serine ratio is increased in the plasma of AKI patients compared with that in healthy subjects. Data are shown as mean ± SEM. Statistical analysis was performed using Student’s t test. *P < 0.05. Normal subjects (n = 5) have a D-serine/L-serine ratio of 0.018 ± 0.005 and D-serine values of 2.70 ± 0.48 μm; AKI patients have a D-serine/L-serine ratio of 0.075 ± 0.060 and D-serine values of 7.77 ± 5.16 μm. (B) Serum D-serine levels are correlated with an increase in creatinine (Cr) and a decrease in estimated glomerular filtration rate (eGFR). (C) Proposed model of the relationship between gut-derived D-serine and the kidney based on the results of this study.