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. 2018 Oct 18;3(20):e121958. doi: 10.1172/jci.insight.121958

Figure 2. Kisspeptin (KP) modulates resting-state functional connectivity to enhance sexual brain processing and reduce sexual aversion.

Figure 2

(A) KP administration enhances default mode network (DMN) connectivity more in participants with lower baseline drive reward scores (Behavioral Activation System [BAS] drive). (B) KP’s modulation of DMN connectivity correlates with subsequent increases in posterior cingulate cortex (PCC), and (C) globus pallidus activity in response to sexual images. (D and E) KP’s modulation of DMN (D) and salience network (E) connectivity correlates with reduced sexual aversion (Sexual Arousal and Desire Inventory–Negative). Two-tailed partial correlation testing, adjusted for visit order. n = 29 per group.