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. 2018 Oct 18;3(20):e121958. doi: 10.1172/jci.insight.121958

Figure 4. Kisspeptin (KP) enhances hippocampus–globus pallidus ROI connectivity and this predicts brain responses to negative images.

Figure 4

(A) KP administration enhanced functional connectivity between anatomically defined hippocampus and globus pallidus (P = 0.0004). Fisher’s transformation used to convert r values into Z values followed by 2-tailed paired t test with Bonferroni’s correction. n = 29 per group. (B) KP’s enhancement of hippocampus–globus pallidus connectivity correlated with increased brain activity in the posterior cingulate cortex (PCC), (C) thalamus, and (D) medial frontal gyrus (MFG). Two-tailed partial correlation testing, adjusted for visit order. n = 29 per group.