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. 2018 Oct 4;3(19):e120596. doi: 10.1172/jci.insight.120596

Figure 2. Macrophage polarization in BMDMs and IR-stressed livers mHO-1–KO mice.

Figure 2

Levels of mRNAs encoding CXCL10, IL-1β, and MCP1 (M1 markers); and Arg1 and CD163 (M2 markers) in BMDMs treated with LPS (A) or IL-4 (B), harvested from mHO-1–KO mice. Data were normalized to HPRT gene expression (n = 4/group) and are representative of 3 independent experiments. (C) Hepatic levels of mRNAs encoding CXCL10, IL-1β, and MCP1 (M1 markers); and Arg1 and CD163 (M2 markers) after liver IRI in mHO-1–KO mice versus controls (n = 4/group). Similar results were obtained from 3 independent experiments. Data are shown as the mean ± SEM (scatter dot blot). Statistical analyses were done with 2-tailed Mann-Whitney U test. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.