Figure 3. Moving average of standardized pathogenesis-based transcript (PBT) scores and archetype scores in biopsies ordered by increasing time after transplant (period = 100 biopsies).

The S4_injury score is compared to injury PBT scores (A) and rejection-related scores (B). Time after transplant is given in days, reported on a logarithmic scale. The S2_TCMR, S3_ABMR, and S4_UV scores are all taken from the 4-archetype model (4AA). PC3, principal component 3 from principal component analysis of 889 EMBs based on rejection-associated transcript expression; IRIT5, 5-day injury-and-repair-induced kidney transcripts; cIRIT, cardiac injury-and-repair-induced transcripts; IRRATs, kidney injury-and-repair-associated transcripts; DAMP, damage-associated molecular pattern transcripts; QCMATs, macrophage-associated transcripts; QCATs, effector T cell–associated transcripts.