Table 3. Univariate and multivariate Cox regression analyses of prognostic factors for disease-free survival.

		Univariate analysis			Multivariate analysis
		CI 95%	HR	p value	CI 95%	HR	p value
Age
	≤ 65	0.30-4.28	1.13 1.00 (ref.)	0.852
	> 65
Gender
	Female	0.56-8.33	2.17 1.00 (ref.)	0.259
	Male
pT stage
	pT1-T2	4.81-69.76	18.3 1.00 (ref.)	< 0.001	1.08-55.7	7.78 1.00 (ref.)	0.041
	pT3-T4
Fuhrman grade
	1-2	0.73-7.98	2.42 1.00 (ref.)	0.144
	3-4
Surgical margin
	Positive	0.13-8.58	1.09 1.00 (ref.)	0.933
	Negative
Collecting system invasion
	Yes	2.64-28.52	8.68 1.00 (ref.)	< 0.001	0.72-17.82	3.6 1.00 (ref.)	0.116
	No
Microvascular invasion
	Yes	3.48-67.51	15.32 1.00 (ref.)	< 0.001	0.72-48.48	5.92 1.00 (ref.)	0.097
	No
Tumor necrosis
	Yes	2.19-23.92	7.24 1.00 (ref.)	0.001	0.84-25.13	4.6 1.00 (ref.)	0.078
	No
Albumin / globulin ratio
	≤ 1.40	1.23-26.55	5.72 1.00 (ref.)	0.026	0.36-15.10	2.34 1.00 (ref.)	0.372
	> 1.40
Neutrophil / Lymphocyte ratio
	≤ 2.45	0.01-1.00	7.79 1.00 (ref.)	0.051
	> 2.45
Platelet / Lymphocyte ratio
	≤ 148	0.55-6.03	1.82 1.00 (ref.)	0.323
	> 148
Lymphocyte / monocyte ratio
	< 4	0.24-7080	4.18 1.00 (ref.)	0.154
	≥ 4						-

CI = Confidence interval; HR = Hazard ratio; Ref = Reference