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Inhibition of XPO1 down‐regulates Mcl‐1 and prevent up‐regulation of Mcl‐1 induced by ABT‐199. (A and B) THP‐1, OCI‐AML3, and MV4‐11 cells were treated with ABT‐199 and/or KPT‐330/KPT‐8602 for 24 hours. Whole cell lysates were subjected to Western blotting and probed with the indicated antibodies. Relative densitometry measurements of Mcl‐1, Bim, Bcl‐2, Bax, Bak, and Bcl‐xL were performed using Odyssey Software V3.0
