Figure 6.

Gentisic acid reduces interstitial and perivascular fibrosis in mice with transverse aortic constriction (TAC). Representative images of Masson's trichrome staining of the hearts of mice in the sham and TAC + vehicle, gentisic acid, bisoprolol, or diltiazem groups. Scale bar = 50 μm. A, Interstitial fibrosis and B, perivascular fibrosis are shown. Fibrotic areas are stained blue. C, Fibrotic areas in specimens from the sham, TAC, and drug‐treated TAC groups were quantified (n = 6 per group). Data are means ± SE. ***P < 0.001; ^## P < 0.01 and ^### P < 0.001 vs the TAC group