Table 1.
Blood morphology in analysed experimental groups of mice 28 d after orthotopic inoculation of 4T1 tumour cells
| Parameter | Control | dCF | 4T1 | 4T1 + dCF |
|---|---|---|---|---|
| RBC (T/L) | 5.34 ± 0.92 | 4.69 ± 0.71 | 6.05 ± 0.31 | 6.43 ± 0.25 |
| Haemoglobin (mmol/L) | 5.39 ± 0.83 | 4.94 ± 0.89 | 6.50 ± 0.26 | 6.65 ± 0.25 |
| Haematocrit (%) | 25.8 ± 0.04 | 22.8 ± 0.06 | 29.0 ± 0.10 | 31.0 ± 0.10 |
| MCV (fL) | 48.8 ± 0.66 | 49.0 ± 0.63 | 48.6 ± 0.30 | 48.4 ± 0.30 |
| MCHC (mmol/L) | 21.1 ± 0.48 | 21.7 ± 0.29 | 22.3 ± 0.64 | 21.4 ± 0.20 |
| WBC (G/L) | 1.92 ± 0.49 | 2.56 ± 0.84 | 197 ± 43.4* | 116 ± 39.4 |
| Lymphocytes (%) | 60.8 ± 7.39 | 63.0 ± 5.11 | 10.4 ± 1.63*,** | 15.7 ± 3.90*,** |
| Monocytes (%) | n.o. | n.o. | 1.00 ± 0.85 | 0.29 ± 0.29 |
| Segmented neutrophil granulocytes (%) | 38.8 ± 7.30 | 36.8 ± 5.29 | 81.43 ± 2.17*,** | 80.1 ± 2.65*,** |
| Banded neutrophil granulocytes (%) | n.o. | n.o. | 5.57 ± 1.25 | 3.29 ± 1.36 |
| Eosinophil granulocytes (%) | 0.40 ± 0.24 | 0.10 ± 0.09 | 1.29 ± 0.52 | 0.57 ± 0.30 |
| Platelets (G/L) | 469 ± 178 | 458 ± 227 | 981 ± 108 | 915 ± 112 |
Peripheral blood morphology in BALB/c mice 28 d after orthotopic injection of PBS, treated with PBS (control, n = 5) or 0.2 mg/kg dCF (dCF, n = 5) or after orthotopic injection of 4T1 cancer cells treated with PBS (4T1, n = 7) or 0.2 mg/kg dCF (4T1 + dCF, n = 7) every 3 d for 28 d of the experiment. Data are presented as mean ± SEM, n.o., not observed per 200 cell counted, *P < 0.05 vs control, **P < 0.05 vs dCF by one‐way ANOVA followed Holm‐Sidak post hoc test.