Figure 11.

Mechanism by which the Tp92 protein mediates IL‐8 secretion. A and B, Concentration of secreted IL‐8 measured by ELISA. A, The cells were pretreated with CD14 (10 μg/mL), TLR2 (10 μg/mL) or TLR4 (10 μg/mL) for 1 hour before treatment with Tp92 (5 μg/mL), PGN (10 μg/mL), or LPS (1 μg/mL) for 12 hours. *P < 005. B, The cells were pretreated with the siRNA of TLR2 (2 μg/mL) and TLR4 (2 μg/mL) for 24 hours before treatment with Tp92 (5 μg/mL) for 12 hours. *P < 005