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. 2018 Sep 30;22(12):6338–6344. doi: 10.1111/jcmm.13932

Figure 5.

Figure 5

STAT3 accelerated CASC9 expression through binding with its promoter. A, The schematic diagram showed the binding within STAT3 and CASC9 promoter region, including two predicted sites (P1, P2). B, STAT3 protein expression level in U87 cell transfected with STAT3 recombinant plasmid. C, RT‐PCR revealed the CASC9 expression in U87 cell transfected with STAT3 recombinant plasmid. D, ChIP analysis showed the binding affinity in two candidate sites (P1, P2). E, Luciferase reporter assay revealed the activity within STAT3 and CASC9 wild‐type or mutant. *P < 0.05, **P < 0.01 compared to control group