Table 1.
Caenorhabditis elegans macrocyclic lactone resistance mutants isolated in forward mutagenic screens.
| Mutant strain | Resistance screen | Dyf amphid | ABZ R (100 µM) |
|---|---|---|---|
| TP236(ka30) | IVM 10 nM screen 1 | Dyf − | No |
| TP237(ka31) | ABM 50 nM screen 2 | Dyf − | No |
| TP238(ka32) | IVM 10 nM screen 1 | Dyf + | No |
| TP239(ka33) | IVM 10 nM screen 1 | Dyf + | No |
| TP240(ka34) | ABM 50 nM screen 3 | Dyf − | No |
| TP241(ka35) | ABM 50 nM screen 3 | Dyf − | Yes |
| TP242(ka36) | ABM 50 nM screen 3 | Dyf − | No |
| TP243(ka37) | ABM 50 nM screen 3 | Dyf − | No |
| TP249(ka43) | ABM 50 nM screen 3 | Dyf − | No |
| TP250(ka44) | IVM 10 nM screen 1 | Dyf − | No |
| TP271(ka63) | IVM 10 nM screen 4 | Dyf − | No |
| TP272(ka64) | IVM 10 nM screen 4 | Dyf − | No |
| TP273(ka65) | IVM 10 nM screen 4 | Dyf − | No |
| TP274(ka66) | IVM 10 nM screen 4 | Dyf − | No |
| TP275(ka67) | IVM 10 nM screen 4 | Dyf − | No |
| TP173(ka98) | IVM 10 nM screen 1 | Dyf − | No |
| TP153(ka99) | IVM 10 nM screen 1 | Dyf − | No |
Dyf, amphid dye-filling; IVM, ivermectin; ABM, abamectin; ABZ R, albendazole resistant.