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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Pain. 2018 Dec;159(12):2620–2629. doi: 10.1097/j.pain.0000000000001373

Table 1. The 12/15-Lipoxygenase family of enzymes.

Pathway Common
Name		 Gene Protein Activity (rat) Activity (human) % ID
12-LOX platelet-type
12(R)-type

epidermis-type		 Alox12
Alox12b
Alox12e
Aloxe3 		12-LOX-p
12(R)-LOX
12-LOX-e
eLOX3		 12(S)-LOX; HXS
12(R)-LOX
12(R)-LOX(low)
HXS		 12(S)-LOX; HXS, LXS
12(R)-LOX
pseudogene
HXS		 84
87
-
88
15-LOX leukocyte-type Alox15
Alox15b 		15-LOX-1
15-LOX-2		 12(S)-LOX; HXS
15-LOX		 15-LOX
15-LOX		 75
81

12-LOX = 12-lipoxygenase; HXS = hepoxilin synthase; 15-LOX = 15-lipoxygenase; LXS = lipoxin synthase; % ID = Percent identity of each rat enzyme to its human ortholog.