Table 2:
Comparison of global (patient-level) coronary wall properties between 1-month and 12-month post HTx. Advanced_IT is defined as IT>120μm, threshold identified to give the strongest quantitative differences between 1-month and 12-month measurements. Statistically significant differences shown in bold, p-values reported after Bonferroni correction.
| 1-month | 12-month | Difference | p-value | |
|---|---|---|---|---|
| Lumen Area (mm2) | 8.6±2.5 | 7.6±2.3 | −1.0±1.6 | 0.039 |
| Intimal thickness (μm) | 103.0±31.8 | 129.6±41.7 | 26.5±25.9 | 0.001 |
| Medial thickness (μm) | 81.3±19.4 | 81.5±18.6 | 0.2±11.1 | 0.966 |
| Intimal+Medial thickness (μm) | 184.3±47.4 | 211.0±56.5 | 26.7±33.2 | 0.012 |
| Normalized Intimal thickness (μm/mm2) | 13.9±7.0 | 19.6±9.8 | 5.7±7.3 | 0.001 |
| IMratio | 1.4±0.3 | 1.7±0.4 | 0.3±0.3 | <0.001 |
| Intimal roughness | 0.36±0.10 | 0.42±0.10 | 0.06±0.15 | 0.002 |
| Medial roughness | 0.37±0.10 | 0.43±0.09 | 0.06±0.13 | 0.004 |
| Intimal brightness | 40.4±13.8 | 38.1±12.7 | −2.3±17.7 | 0.392 |
| Medial brightness | 40.4±14.1 | 38.4±13.5 | −2.0±18.6 | 0.461 |
| Intimal-to-Medial brightness ratio | 1.04±0.05 | 1.04±0.05 | 0.01±0.07 | 0.587 |
| Advanced_IT (%) | 25.1%±20.1% | 43.1%±26.1% | 18.0%±17.4% | <0.001 |
| Absolute area of Advanced_IT (mm2) | 43.9±37.7 | 71.3±48.1 | 27.4±27.2 | 0.002 |
| Largest area of Advanced_IT (mm2) | 27.9±36.3 | 53.1±48.1 | 25.2±34.4 | 0.004 |