Table 1.
Progress of CLP-PEG and RHCIII-MPC implants grafted into corneas of mini-pigs, compared to untreated contralateral control eyes over the 12 month post-operation period.
| Treatment | Time | Cornea thickness (mm) | Haze | Vascularization |
Schirmer's tear test (mm) | Aesthesiometry (mm) | IOP (mmHg) | |
|---|---|---|---|---|---|---|---|---|
| Implant | Margin | |||||||
| CLP-PEG | Pre-op | 706 ± 20 | 0 | 0 | 0 | 12 ± 3 | 3.9 ± 0.3 | 10 ± 1 |
| 1 m | – | 0.38 | 0.5 | 1.75 | 7 ± 1 | 0 | – | |
| 3 m | 690 ± 16 | 0.25 | 1.75 | 0 | 13 ± 3 | 1.3 ± 0.4 | 16 ± 2 | |
| 6 m | 702 ± 22 | 0 | 0 | 0.75 | 12 ± 1 | 3.4 ± 0.1 | 16 ± 2 | |
| 9 m | 724 ± 13 | 0 | 0 | 0.5 | 16 ± 2 | 2.9 ± 0.1 | 19 ± 8 | |
| 12 m | 747 ± 8 | 0 | 0 | 2 | 13 ± 4 | 3.4 ± 0.1 | 22 ± 2 | |
| RHCIII-MPC | Pre-op | 704 ± 21 | 0 | 0 | 0 | 11 ± 3 | 4.4 ± 0.6 | 11 ± 1 |
| 1 m | – | 0.38 | 0.5 | 0.5 | 7 ± 2 | 0 | – | |
| 3 m | 652 ± 9 | 0.69 | 1.75 | 0.5 | 15 ± 2 | 0.4 ± 0.4 | 14 ± 2 | |
| 6 m | 669 ± 22 | 0 | 0 | 2 | 13 ± 2 | 3.3 ± 0.4 | 20 ± 2 | |
| 9 m | 687 ± 11 | 0 | 0 | 0 | 13 ± 4 | 2.9 ± 0.2 | 16 ± 2 | |
| 12 m | 693 ± 23 | 0 | 0 | 0 | 15 ± 4 | 3.8 ± 0.1 | 15 ± 1 | |
| Untreated | Pre-op | 725 ± 11 | 0 | 0 | 0 | 8 ± 2 | 4.4 ± 0.3 | 11 ± 1 |
| 1 m | – | 0 | 0 | 0 | 9 ± 1 | 4.1 ± 0.4 | – | |
| 3 m | 730 ± 10 | 0 | 0 | 0 | 12 ± 2 | 3.4 ± 0.1 | 17 ± 2 | |
| 6 m | 738 ± 10 | 0 | 0 | 0 | 10 ± 1 | 3.9 ± 0.1 | 17 ± 3 | |
| 9 m | 747 ± 11 | 0 | 0 | 0 | 13 ± 3 | 3.3 ± 0.3 | 16 ± 6 | |
| 12 m | 767 ± 11 | 0 | 0 | 0 | 15 ± 2 | 3.6 ± 0.2 | 18 ± 2 | |