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. 2018 Jul 11;37(46):6041–6053. doi: 10.1038/s41388-018-0403-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — MUC20 knockdown suppresses PDAC tumour growth in immunodeficient mice. a Western blots showing stable MUC20 knockdown in HPAC and HPAF-II cells. MUC20 knockdown inhibited viability in HPAC and HPAF-II cells analysed by MTT assays. Cells were stably transfected with MUC20 shRNA (sh-MUC20) or non-targeting control shRNA (sh-Control). Data are presented as mean (n = 3) ± SD. b MUC20 knockdown decreased tumour sizes (upper) and weights (lower) compared with the control group (n = 5 for each group) after four weeks of intraperitoneal injection with HPAC or HPAF-II cells in nude mice. Data are presented as mean ± SEM. c MUC20 knockdown decreased tumour sizes (upper) and weights (lower) compared with the control group (n = 6 for each group) after four weeks of subcutaneous injection with HPAF-II cells in NOD/SCID mice. d The left panel shows MUC20 knockdown decreased tumour sizes (upper) and weights (lower) compared with the control group (n = 7 for each group) after four weeks of orthotopic injection with HPAF-II cells in NOD/SCID mice. The right panel shows representative images of IHC for MUC20 in control and MUC20 knockdown tumours. Data are presented as mean ± SEM. *P < 0.05; **P < 0.01