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. 2018 Nov 15;8:16840. doi: 10.1038/s41598-018-35393-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Chemical structure of the natural and synthetic mannoconjugates evaluated. AraLAM, lipoarabinomannan devoid of caps; LM: lipomannan; ManLAM, mannose-capped lipoarabinomannan; M(L)P, manno(lipo)proteins; M2M, M2D, second-generation mannodendrimers capped with mono- or di-mannosides respectively; PILAM, phospho-myo-inositol-capped lipoarabinomannan; PIM₄, phosphatidyl-myo-inositol tetramannosides; PIM₆: phosphatidyl-myo-inositol hexamannosides; RruLAM; LAM from R. ruber; SaeLM, LM from S. aerocolonigenes; TotLAM, LAM from T. otitidis; TpaLAM, LAM from Ts. paurometabola. Detailed structures are shown in Fig. S1. (b+/−, s+/−) indicates the ability (+) or not (−) of the mannoconjugates to bind (b) or induce signaling (s) via Dectin-2.