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. 2018 Aug 23;46(20):10682–10696. doi: 10.1093/nar/gky752

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — The model for the regulatory network integrating three candidate TFs (YiaJ, YdcI, and YeiE) and their biological functions in E. coli K-12 MG1655. (A) YiaJ is a regulator that controls the operon yiaK-yiaL-yiaM-yiaN-yiaO-lyxK-sgbH-sgbU-sgbE in the catabolism pathway. (B) YdcI inhibits the transcription of target gene gltA, resulting in the down-regulation of citrate synthase that is required in the TCA cycle. (C) YdcI binds to genomic DNA and activates target genes nhaA, dtpA, lldP, and gltP that are responsible for proton transfer. (D) YeiE affects multiple transporters (amino acids, inorganic ions, lipids) and metabolic processes, maintaining iron homeostasis at iron-limited conditions.