Table 4.
Association between RD and 6-year mortality according to EF (Univariate analysis and Multiple Cox analysis)
| Univariate analysis | Multiple Cox analysis | |||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| EF >50% | ||||
| RD | 1.61 (0.55-2.90) | 0.367 | 0.59 (0.14-1.41) | 0.461 |
| eGFR 30-60 mL/min/1.73 m2 | 1.08 (0.89-1.98) | 0.898 | 0.98 (0.89-1.01) | 0.887 |
| eGFR 15-30 mL/min/1.73 m2 | 0.98 (0.89-1.01) | 0.999 | 0.87 (0.85-1.02) | 0.998 |
| Age (years) | 1.05 (1.01-1.09)0 | 0.027 | 1.05 (1.01-1.08) | 0.025 |
| Diabetes | 2.23 (1.05-5.95) | 0.050 | ||
| Hypertension | 2.35 (1.05-7.11) | 0.042 | ||
| Heart failure at admission | 6.29 (1.31-10.17) | <0.001 | 4.79 (1.83-10.12) | 0.038 |
| Peak CK | 1.01 (1.02-1.04) | 0.010 | ||
| 3-vessel diasease | 1.95 (1.10-4.99) | 0.040 | ||
| EF 40-50% | ||||
| RD | 2.94 (1.97-1.39) | <0.001 | 2.52 (1.54-3.78) | 0.001 |
| eGFR 30-60 mL/min/1.73 m2 | 3.04 (2.34-10.94) | <0.001 | 2.22 (1.52-5.35) | 0.001 |
| eGFR 15-30 mL/min/1.73 m2 | 4.32 (3.95-31.5) | <0.001 | 3.64 (1.35-7.57) | <0.001 |
| Age (years) | 1.09 (1.06-1.11) | <0.001 | 1.04 (1.01-1.07) | 0.002 |
| Previous MI | 1.45 (1.31-2.93) | 0.050 | ||
| Diabetes | 2.68 (1.60.4.40) | 0.001 | ||
| Hypertension | 1.78 (1.03-2.78) | 0.048 | ||
| Heart failure at admission | 5.10 (3.04-8.59) | <0.001 | 3.20 (1.93-5.33) | <0.001 |
| Sytolic blood pressure at admission (mm Hg) | 1.01 (0.98-1.02) | 0.871 | ||
| Heart rate admission /min | 1.02 (1.01-1.03) | 0.060 | ||
| Peak CK | 1.02 (1.01-1.04) | 0.030 | ||
| 3-vessel disease | 2.14 (1.31.3.50) | 0.002 | ||
| Post-procedural flow TIMI<3 | 3.45 (1.56-5.64) | 0.001 | 1.90 (0.96-3.05) | 0.097 |
| EF <40% | ||||
| RD | 6.76 (4.21-10.89) | <0.001 | 2.84 (1.68-5.34) | <0.001 |
| eGFR 30-60 mL/min/1.73 m2 | 3.34 (2.15-7.18) | <0.001 | 2.62 (1.95-3.59) | <0.001 |
| eGFR 15-30 mL/min/1.73 m2 | 13.01 (3.25-20.9) | <0.001 | 3.72 (2.80-10.14) | <0.001 |
| Age (years) | 1.05 (1.01-1.07) | 0.001 | ||
| Previous MI | 1.44 (0.92-2.51) | 0.042 | ||
| Diabetes | 1.39 (1.27-2.35) | 0.037 | ||
| Hypertensio | 1.25 (1.15-1.95) | 0.050 | ||
| Heart failure at admission | 3.46 (2.11-5.68) | <0.001 | 1.93 (1.29-2.91) | |
| Systolic blood pressure at admission (mm Hg) | 1.01 (0.99-1.03) | 0.001 | ||
| Heart rate at admission/min | 1.01 (0.99-1.03) | 0.002 | ||
| Peak CK | 1.02 (1.01-1.04) | 0.020 | ||
| 3-vessel disease | 2.14 (1.32-3.46) | 0.002 | ||
| Post-procedural flow TIMI<3 | 5.34 (2.87-9.95) | <0.001 | 2.07 (1.36-3.15) | <0.001 |
EF- ejection fraction; MI - myocardial infarction; RD - renal dysfunction (eGFR<60 mL/min/1.73 m2); eGFR- estimated glomerular filtration rate; CK - creatinine kinase