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. 2018 Aug 14;46(20):10669–10681. doi: 10.1093/nar/gky749

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — A model for LDL1/2 and HDA6 functions in the regulation of circadian clock central oscillator TOC1. The morning accumulated-CCA1/LHY interact with the histone modification complex containing LDL1/2 and HDA6. CCA1/LHY act as transcription repressors and recruit the histone modification complex to their targets loci such as TOC1. In the evening, CCA1/LHY are low expressed, and TOC1 is highly expressed because the LDL1/2-HDA6 complex is released from the TOC1 promoter.