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. 2018 Oct 10;46(20):10888–10904. doi: 10.1093/nar/gky896

Table 1.

Kinetic parameters of MTH1

K m (μM) k cat (s−1) k cat/Km (M−1s−1)
O6-methyl-dGTP 15.6 ± 0.2 8.2 ± 0.9 515 000 ± 80 000 n = 2
O6-methyl-GTP 236 ± 44 0.3 ± 0.1 1160 ± 580 n = 2
8-oxo-dGTP* 13.2 3.3 246 200
10.2 8.6 840 200

*Data from (17), and (41), n denotes number of experiments. kcat, KM and kcat/KM values were determined by fitting the Michaelis–Menten equation to initial rates using non-linear regression analysis utilizing the GraphPad Prism Software. Values shown are average and standard deviations.