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. 2018 Aug 29;46(20):10905–10916. doi: 10.1093/nar/gky745

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Efficacy distribution of the panel of chemically modified, asymmetric, self-delivering siRNAs (sdRNAs). (A) sdRNAs are asymmetric siRNAs, consisting of a 20-nucleotide antisense strand and a 15-nucleotide sense strand, in which all pyrimidines are 2′-fluoro (antisense) and 2′-O-methyl (sense) modified. The 3′ terminal backbone is phosphorothioated (six linkages in antisense and two in sense). The 3′ end of the sense strand is conjugated to cholesterol. (B) The efficacy of 356 sdRNAs targeting 17 genes was evaluated using dual luciferase reporter in HeLa cells at 1 μM (passive uptake) at 48 h (n = 3, mean ± SD).