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. 2018 Aug 29;46(20):10905–10916. doi: 10.1093/nar/gky745

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — sdRNA algorithm accurately predicts efficacy using two independent datasets. The sdRNA (24%/NF) algorithm was applied to predict the efficacy of (A) 50 sdRNAs targeting five genes (qPCR, sdRNAs inducing ∼ <25% target gene expression are defined as functional). sdRNA algorithm predicts efficacy with ∼60% accuracy at ∼30% sensitivity. (B) 94 sdRNAs targeting the huntingtin gene (QuantiGene (34), sdRNAs inducing ∼ <25% target gene expression are defined as functional). sdRNA algorithm predicts efficacy with ∼80% accuracy at ∼25% sensitivity. Black line shows performance of the control algorithm (see Methods).