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. 2018 Nov 15;8:16903. doi: 10.1038/s41598-018-35043-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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hTERT inhibition and toxicity by activation of LC PCBs. (A) Jurkat T cells were treated with increasing concentrations of parent PCBs or OH-metabolites for 48 hrs. as indicated. hTERT mRNA expression was evaluated by RT-PCR with expression levels normalized against 18S rRNA. Mean ± SD of three different experiments each with a total of three replicates are shown. Statistical analysis was performed by an unpaired, two-tailed Student’s t-test. Statistically significant differences are indicated (*P < 0.05). (B) Jurkat T cells were incubated as described in (A). Mitochondrial and cellular viability were assessed by means of MTT-assay performed as described. Mean ± SD of three different experiments each with a total of three replicates are shown. Statistical analysis was performed by an unpaired, two-tailed Student’s t-test. Statistically significant differences are indicated (*P < 0.05; **P < 0.01; ***P < 0.0005; ****P < 0.0001).