Table 1.
Overview of clinical experience with 225Ac- and 213Bi-labeled compounds.
| Cancer type | Radioconjugate | Patients | References |
|---|---|---|---|
| Leukemia | 213Bi-HuM195mAb | 49 | [38,39] |
| - | 225Ac-HuM195mAb | 36 | [40] |
| Lymphoma | 213Bi-anti-CD20-mAb | 12 | [41] |
| Melanoma | 213Bi-9.2.27mAb | 54 | [42-44] |
| Bladder Cancer | 213Bi-anti-EGFR-mAb | 12 | [32,45] |
| Glioma | 213Bi-Substance P | 68 | [46-48] |
| - | 225Ac-Substance P | 19 | [48] |
| Neuroendocrine tumors | 213Bi-DOTATOC | 25 | [4] |
| - | 225Ac-DOTATOC | 39 | [49] |
| Prostate cancer | 225Ac-PSMA-617 | 190 | [5,50,51] |