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. 2018 Nov 15;9(12):1138. doi: 10.1038/s41419-018-1186-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a hMMP-2/9 mRNA levels were determined after siPLOD3 treatment in vivo. Statistical significance was determined by Student’s t-test. *P < 0.05; **P < 0.01. b In vivo immunofluorescence of siCON- and siPLOD3-treated groups. c hMMP-2/9 and hu-PA mRNA levels after the indicated concentration of HA-PLOD3 was transfected were determined via quantitative reverse transcription polymerase chain reaction (RT-qPCR). Statistical significance was determined by Student’s t-test. *P < 0.05. d H460 cells were transfected with siCON or the indicated concentration of siPLOD3 for 24 h. hMMP-2/9 and hu-PA mRNA levels were determined via RT-qPCR. Statistical significance was determined by ANOVA analysis. **P < 0.01, ***P < 0.001. e–g Correlation of hPLOD3 with hMMP-2 or hMMP-9 or hu-PA transcripts in the cbioportal datasets of lung cancer patients