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. 2018 Nov 15;9(12):1138. doi: 10.1038/s41419-018-1186-5

Fig. 5. PLOD3 regulated the malignant phenotype via STAT3 signaling.

Fig. 5

a Immunostaining of PLOD3, pS-STAT3, and STAT3 in PLOD3 knockdown xenograft tumors. b Protein levels of PLOD3, pS-STAT3, pY-STAT3, and STAT3 were determined via western blotting in PLOD3 xenograft tumors. Statistical significance was determined by Student’s t-test. *P < 0.05, **P < 0.01. c Levels of the indicated proteins were determined via western blotting after siPLOD3 treatment in R-H460 cells. d Levels of the indicated proteins were determined via western blotting in HA-PLOD3-overexpressing H460 cells. e, f The HA-PLOD3 and STAT3 inhibitor S3I-201-treated H460 cells were analyzed via a transwell assay to evaluate cell motility and invasiveness. Statistical significance was determined by Student’s t-test. *P < 0.05; **P < 0.01