Table 1.
Neutrophils in autoimmune diseases.
| Diseases | Species | Effector molecules | Functions | References |
|---|---|---|---|---|
| MS | Mouse | ROS | Destructing blood-brain-barrier | (60, 61) |
| Mouse | MPO | Destructing blood-brain-barrier | (62) | |
| SLE | Human | IFN-á | Damaging vascular endothelia | (13) |
| Human | NETs | Killing endothelial cells and activating plasmacytoid dendritic cells | (14, 63) | |
| RA | Mouse | PADI 4 | Related to the generation of autoantibodies | (15) |
| Human | TNF | Attracting T cells | (64) | |
| Human | B-lymphocyte stimulator | Activating B cells | (65, 66) | |
| Mouse | ROS | Decreased ROS levels is associated with autoimmune and chronic inflammation | (67, 68) | |
| Human | MMPs | Destructing cartilage | (69, 70) | |
| Mouse | RANKL | Resorbing bone | (71) | |
| T1D | Human | NE | Related to the generation of â-cells antigens autoantibodies | (72) |
| Human | Proteinase 3 | Related to the generation of â-cells antigens autoantibodies | (72) | |
| Mouse | ROS | Destructing pancreatic â-cells | (73) | |
| Mouse | CRAMP | Activating plasmacytoid dendritic cells | (16) | |
| IBD | Mouse | ROS | Killing bacteria and damaging intestinal mucusa | (74, 75) |
| Human | MMP-9 | Degrading the extracellular matrix and vascular repairement | (76, 77, 78) | |
| Human | NE | Disrupting intestinal barrier | (79, 80) | |
| Mouse | IL-22 | Repairing epithelial integrity and resoling colitis | (81) |