Table 5.
Summary of significant findings of most important antigens assessed in studies grouped according to antigen families.
| References | Latency associated antigens | Resuscitation promoting factors (Rpfs) | Others | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Dormancy of survival regulon (DosR) | ||||||||||
| Rv0081 | Rv1733c | Rv1737c | Rv2029c | Rv2031c | Rv2628 | HBHA | Rv0867c | Rv2389c | Ag85complex | |
| (18) | NA | NA | NA | NA | NA | NA | NA | NA | NA | Higher concentrations of IFN-γ and Il-17 in exp vs. aTB patients |
| (19) | NA | NA | NA | NA | NA | NA | NA | NA | NA | Higher concentration of IFN-γ in treated aTB patients & community controls vs. untreated patients |
| (20) | NA | NA | NA | Higher concentrations of IFN-γ in LTBI vs. aTB patients & controls | NA | NA | NA | NA | ||
| (21) | NA | NA | Higher proportion of IFN-γ and/or TNF-α-producing CD4 & CD8 T cells in LTBI vs. aTB patients | NA | NS | NA | NS | Higher proportion of IFN-γ and/or TNF-α-producing CD4 or CD8 T cells in LTBI vs. aTB patients | NA | |
| (22) | NA | NA | NA | Higher concentrations of IFN-γ in LTBI vs. aTB patients & controls | NA | Higher concentrations of IFN-γ in LTBI vs. aTB patients & controls | NA | NA | NA | NA |
| (23) | NA | NA | NA | NA | Lower concentrations of IFN-γ, Il-10 & TNF-α in aTB patients vs. controls | NA | NA | NA | NA | NA |
| (25) | NA | NA | NA | NA | NA | NA | Lower concentrations of IFN-γ in HIV+ individuals with aTB & LTBI compared to HIV− patients | NA | NA | NA |
| (26) | Higher concentrations of IFN-γ in exp vs. aTB patients | NS | NS | NA | NA | NA | Higher concentrations of IFN-γ in exp vs. aTB patients | NA | ||
| (27) | Higher concentrations of Il-10, Il-12(p40), IP-10 & TNF-α in exp vs. aTB patients | NA | Higher concentrations of Il-10, Il-12(p40), IP-10 & TNF-α in exp vs. aTB patients | NA | NA | NA | NA | NS | Higher concentrations of TGF-α in aTB patients vs. exp | NA |
| (29) | NA | Higher proportion of IFN-γ/TNF-α-producing CD8 T cells in LTBI vs. healthy controls | NA | Higher proportion of IFN-γ/TNF-α-producing CD8 T cells in LTBI vs. healthy controls | NA | NA | NA | NA | NS | |
| (30) | NA | NA | NA | NA | NA | NA | Higher concentration of IFN-γ in LTBI vs. aTB | NA | NA | NA |
| (31) | NA | NA | NA | NA | NA | NA | Low concentrations of IFN-γ in LTBI & aTB patients infected with HIV | NA | NA | NA |
| (34) | NA | NA | NA | NA | NA | NA | Higher proportion of CD4 T cells producing one or more cytokines in LTBI & aTB patients compared to healthy controls | NA | NA | NA |
| (35) | NA | NA | NA | NA | NS | Higher concentrations of IFN-γ in remote LTBI vs. aTB patients, recent LTBI & controls | NA | NA | NA | NA |
| (37) | NA | NA | NA | NA | NA | NA | Higher concentrations of IFN-γ in LTBI vs. aTB patients | NA | NA | NA |
| (38) | NS | NA | NA | Higher proportion of IFN-γproducing T cells in LTBI vs. aTB patients | NS | NA | NA | NA | NA | NA |
| (39) | High concentrations of Il-6, Il-10 & TNF-α in aTB | NS | NA | NA | NA | NA | High concentrations of TNF-α, Il-10 & Il-6 in aTB | NS | ||
| (41) | NA | NA | NA | NA | NS | NA | Higher proportion of IFN-γ/Il-2/Il-17-producing CD4 T cells in household contacts vs. aTB patients | NA | NA | NS |
| (42) | NA | Increase of Granzyme B, IFN-γ, Il-17 & sIl-2Rα concentrations after treatment of aTB patients | NA | Increase of IFN-γ, granzyem B, Il-17 & sIl-2Rα levels after treatment of aTB patients | NA | Increase of IFN-γ, granzyem B, Il-17 & sIl-2Rα levels after treatment of aTB patients | NA | NA | NA | NA |
| (47) | NA | NA | NA | NA | NA | NS | NA | NA | NA | NA |
| (49) | NA | NA | NA | NA | NA | NA | NA | NA | NA | Higher proportions of IFN-γ producing T cells in household contacts vs. controls |
| (50) | NA | NA | NA | NA | NA | NA | Higher concentration of IFN-γ in LTBI vs. aTB patients and controls | NA | NA | NA |
| (51) | NA | NA | NA | NA | NA | NA | Higher concentrations of IFN-γ compared to 12 other cytokines in HIV+ patients (with LTBI/aTB) | NA | NA | NA |