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. 2018 Nov 15;8:16833. doi: 10.1038/s41598-018-34968-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bioluminescence imaging of EP-induced expression of LucF in transgenic Hsp70 (Hspa1b) LucF mice. Luciferin (30 mg/mouse) was injected intraperitoneally 5 min before imaging (A) Images were acquired 6 h after delivery of electric pulses. (B) Quantification of LucF expression in transgenic mice after EP presented as the fold increase of the signal at the position of electrodes compared to the detected signal in non-treated skin. Groups on the left graph. −PBS: only EP, +PBS: 25 µl of PBS injected intradermally + EP, tdTomato: 25 µl (1 µg/µl) of plasmid tdTomato injected intradermally + EP, EGFP: 25 µl (1 µg/µl) of plasmid EGFP injected intradermally + EP. EP conditions (HV, MV and HV-MV) are those defined in Fig. 1. EGT 25 µl (1 µg/µl) of plasmid EGFP injected intradermally + 8 pulses of 5 ms at 240 V.Positive controls were water bath at designated temperature for 8 min.