FIG 8.

Overview of upregulated gene cluster associated with coenzyme A biosynthesis in B. animalis subsp. lactis Bl-04. (A) The genetic region was annotated in the Bl-04 genome and colored as follows: black, coding sequences; red, rRNAs; and green, tRNAs. The arrows below each gene represent a log₂ ratio fold change between ISO_4, LOG_8, and LOG_32 compared to ISO_0 in descending order, with heat coloring showing downregulation (red) and upregulation (blue) with tetracycline. (B) The raw RPKM expression in Bl-04 for various genes involved in coenzyme A biosynthesis from pantothenate. *, adjusted P < 0.05 and fold change of >2×. Expression of dnaA is shown for reference.