Figure 4.

(A) Wounds of minipigs were topically administered up to 1059 μg/cm² UTTR1147A every other day up to Study Day 21. Wounds were macroscopically observed on days of dosing, which also corresponded with days of dressing change. Clinical observations of all wounds in minipigs on Study Day 11 is presented here and do not indicate a treatment‐related impairment of the wound healing process. (B) Blood was collected from minipigs on Study Days ‐1 (pre‐dosing on Day 1), 3, and 21. Serum amyloid protein A was measured and demonstrated to be slightly elevated 2 days post‐ UTTR1147A administration in wounded minipigs topically administered UTTR1147A. Individual animal responses are shown here