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. 2018 Nov;56:29–38. doi: 10.1016/j.biologicals.2018.09.001

Table 3.

Potency estimates relative to 16/138 for U.S. reference reagent Vi-IgGR1, 2011 and coded samples A to E.

Method Sample GMa
Overall GM Inter-lab GCVb Intra-lab GCV
Laboratory code 1 2 3 4 5 6 7
NIBSC ELISA Vi-IgGR1, 2011 2.80 3.50 2.61 3.75 1.80 2.80 31% 22%
A 1.34 1.47 1.62 1.70 1.15 1.44 16% 10%
B 0.73 0.77 0.74 1.03 0.73 0.79 15% 11%
C 0.85 0.92 0.90 1.21 1.07 0.98 15% 13%
D 0.46 0.50 0.66 0.25 0.25 0.39 54% 20%
E 0.33 0.39 0.38 0.43 0.60 0.42 25% 10%
VaccZyme ELISA Vi-IgGR1, 2011 1.60 2.02 1.60 1.59 1.39 1.63 1.63 11% 13%
A 0.84 1.04 1.18 1.09 1.23 1.21 1.09 15% 10%
B 0.27 0.48 0.47 0.41 0.31 0.39 0.38 24% 9%
C 0.70 0.97 1.01 1.08 0.94 1.22 0.97 20% 11%
D 0.21 0.18 0.25 0.31 0.31 0.29 0.25 24% 14%
E 0.44 0.60 0.65 0.71 0.66 0.69 0.62 19% 13%
In-house ELISA Vi-IgGR1, 2011 1.88 1.89 1.70 5.18
A 0.93 1.17 1.09 1.51
B 0.46 0.41 0.53 1.25
C 1.04 1.01 0.90 1.15
D 0.22 0.33 0.23 0.14
E 0.68 0.66 0.47 0.42

-: No data entered.

GCV≥25%: Font in Bold.

a

GM: Geometric Mean.

b

GCV: Geometric Coefficient of Variation.