REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit monoclonal anti-LIN28A	Abcam	AB63740
Recombinant proteins
LIN28A (aa. 25–181)	This study	NA
LIN28A CSD (aa. 25–120)	This study	NA
Experimental Models: Cell Lines
Human NTera2 cells	ATCC	NA
Human HEK 293 cells	ATCC	NA
Oligonucleotides
RNA-mediated interactome capture: 3´-biotinylated 2´-O-methyl-RNA adaptor: 5´-AGGCUAGGUCUCCC-3´	Metabion GmbH, Planegg, Germany	NA
RBNS: 3´ DNA adaptor: 5´-AAACTGGAATTCTCGGGTGCCAAGG-3´-Amino-C7	Metabion GmbH, Planegg, Germany	NA
RBNS: 5´RNA adaptor: 5´-GUUCAGUAAUACGACUCACUAUAGGG-3´	Metabion GmbH, Planegg, Germany	NA
RBNS: RT primer: 5´-GCCTTGGCACCCGAGAATTCCAGTTT-3´	Metabion GmbH, Planegg, Germany	NA
RBNS: forward PCR primer: 5´-AATGATACGGCGACCACCGAGATCTACACGTTCAGTAATACGACTCACTATAGG-3´	Metabion GmbH, Planegg, Germany	NA
RBNS: reverse PCR primer: 5´-GCCTTGGCACCCGAGAATTCCAGTTT-3	Metabion GmbH, Planegg, Germany	NA
RBNS: read 1 sequencing primer: 5´-GATCTACACGTTCAGTAATACGACTCACTATAGGG-3´	Metabion GmbH, Planegg, Germany	NA
Datasets
LIN28B eCLIP (K562 cells)	ENCODE (Van Nostrand et al., 2016)	ENCSR970NKP
LIN28B eCLIP (HepG2 cells)	ENCODE (Van Nostrand et al., 2016)	ENCSR861GYE
LIN28 CLIP (mES cells)	(Cho et al., 2012)	GSE37114
LIN28 CSD RBNS	This study	SRP149796
Pre-let-7 mediated protein pull-down	(Treiber et al., 2017)
DIS3L2 CLIP (HEK293 cells)	(Ustianenko et al., 2016)
LIN28B knock down and overexpression (HEK293 cells)	(Hafner et al., 2013)
TCGA RNA-seq data	TCGA Data Portal https://gdc.cancer.gov
TCGA miRNA-seq data	Firehorse https://confluence.broadinstitute.org/display/GDAC/Dashboard-Stddata
Software and Algorithms
CLIP data analysis by CTK	(Shah et al., 2017)	http://zhanglab.c2b2.columbia.edu/index.php/CTK
De novo motif analysis of RBNS data by Weeder 2.0	(Pavesi et al., 2001)	http://159.149.160.51/modtools/