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. 2018 Nov 15;16:311. doi: 10.1186/s12967-018-1688-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — The effect of PD on mouse platelet aIIbb3 expression and function. Washed mouse platelets were treated with PD (20 μM) followed by measuring aIIb expression by flow cytometry (mean ± SD, n = 3) (a) and western blot (b). PD or vehicle-treated mouse platelets were infused into thrombocytopenic mice or wild-type mouse followed by measuring platelet count (c) and tail bleeding time (mean ± SD, n = 6) (d) or arterial thrombus formation (mean ± SD, n = 6) (e) respectively. Comparison between Vehicle and PD, **P < 0.01; Comparison between Control and Vehicle, ***P < 0.001. Control in d indicates platelet depleted mice without transfusing WT platelets