Table 3.
Association between the general cognitive factor and inflammatory markers in breast cancer survivors and in non-exposed participants
| Inflammatory marker per SD increase | Breast cancer survivors | Non-exposed participants | P for interaction† |
|---|---|---|---|
| Mean difference* (95% CI) | Mean difference* (95% CI) | ||
| Model I | |||
| Log GLR | −0.24 (−0.40 to −0.08) | −0.04 (−0.09 to 0.00) | 0.061 |
| Log PLR | −0.13 (−0.29 to 0.03) | 0.05 (0.01 to 0.10) | 0.003 |
| Log SII | −0.22 (−0.38 to −0.07) | −0.03 (−0.08 to 0.01) | 0.053 |
| Model II | |||
| Log GLR | −0.23 (−0.39 to −0.08) | −0.02 (−0.07 to 0.02) | 0.038 |
| Log PLR | −0.18 (−0.33 to −0.02) | 0.03 (−0.01 to 0.08) | 0.003 |
| Log SII | −0.23 (−0.38 to −0.07) | −0.01 (−0.06 to 0.03) | 0.033 |
Abbreviations: CI confidence interval, GLR granulocyte-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, SD standard deviation, SII systemic immune-inflammation index
Model I is a linear regression of the general cognitive factor on each log-transformed inflammatory marker adjusted for age and education. Model II is as model I plus adjustment for smoking status, body mass index, diabetes mellitus, history of stroke, history of myocardial infarction, and Center for Epidemiologic Studies Depression Scale (CES-D) sum-score
*Mean difference in general cognitive factor per standard deviation increase in inflammatory marker
†P value for interaction term between history of cancer/cancer treatment and inflammatory marker